The compound 4 then reacted with sodium methoxide,methanol and 4,6-dichloropyrimidine in tetrahydrofuran to produce methyl(E)-2-[2-(6-chloropyrimidi.
首先以鄰羥基苯乙酸(2)為原料與原甲酸三甲酯在醋酐中反應制備3-(α-甲氧基)-亞甲基苯并呋喃-2(3氫)-酮(4),收率59%;化合物4再與甲醇鈉、4,6-二氯嘧啶在四氫呋喃中反應得到(E)-2-[2-(6-氯嘧啶-4-基氧基)苯基]-3-甲氧基丙烯酸甲酯(6),收率60%;化合物6與水楊腈反應得到嘧菌酯(1),收率81%。
4,6-Dihydroxypyrimidine was prepared from formamide and dimethyl malonate and then converted to 4,6-dichloropyrimidine (purity 98.
以甲酰胺、丙二酸二甲酯為原料合成4,6-二羥基嘧啶,然后采用三氯氧磷氯化法合成4,6-二氯嘧啶。
Guanidine nitrate and diethyl malonate were used as main materials to prepare 2-amino-4,6-dicarboxyl pyrimidine by cyclization,followed by chloridization to prepare 2-amino-4,6-dichloropyrimidine,and then by methoxidization to prepare 2-amino-4,6-dimethoxy pyrimidine.
以硝酸胍和丙二酸二乙酯為原料,經過環合生成2-氨基-4,6-二羥基嘧啶,氯化生成2-氨基-4,6-二氯嘧啶,再經甲氧基化得最終產品2-氨基-4,6-二甲氧基嘧啶。
Copyright ? mingxiaow.com All Rights Reserved. 杭州優配網絡科技有限公司 版權所有 未經書面允許不得轉載、復制信息內容、建立鏡像
本網站內容僅供參考,請以各學校實際情況為主!內容侵權或錯誤投訴:841539661@qq.com 工信部備案號:浙ICP備20019715號